Iodopropynyl butylcarbamate CAS NO.55406-53-6

1. History of IPBC

Iodopropynyl butylcarbamate (IPBC, CAS# 55406-53-6) is a preservative agent originally used in the wood and paint industries, now also used in some cosmetics and personal care formulations.

IPBC is an effective fungicide at very low concentrations in cosmetic and other products, and has shown very low sensitivity in humans tested with this preservative. IPBC was approved in 1996 for use up to 0.1% concentrations in topical products and cosmetics. However, this preservative is mostly found in cosmetics at about one-eighth that level [Maier et al., 2009]. IPBC Toxicity and Safety Tests show it to be generally safe: When used properly in leave-on skin products, IPBC is extremely safe [Steinberg, 2002]. Previous to being approved for cosmetic use in 1996, extensive safety and toxicity tests were conducted on IPBC and their results were gathered along with earlier studies in a report of the Safety Assessment of IPBC by the Cosmetic Ingredient Review [CIR Final Report, Lanigan 1998]. This final report found IPBC to be a non-carcinogen with no genotoxicity and in reproductive and developmental toxicity studies using rats and mice, IPBC had no significant effect on fertility, reproductive performance, or on the incidence of fetal malformation [Lanigan, 1998].

2. Specification of IPBC

Appearance: White or off white crystal or crystalline powder

Purity (HPLC): 99.0%min.

Melting point: 64-68°C

Moisture : 0.2%max.

3. Application of IPBC

a. Treatment of freshly sawn lumber

b. In-can preservative for paints

c. Mildewcide for paper industry

d. Preservative for cosmetics

1. History of IPBC

Iodopropynyl butylcarbamate (IPBC, CAS# 55406-53-6) is a preservative agent originally used in the wood and paint industries, now also used in some cosmetics and personal care formulations.

IPBC is an effective fungicide at very low concentrations in cosmetic and other products, and has shown very low sensitivity in humans tested with this preservative. IPBC was approved in 1996 for use up to 0.1% concentrations in topical products and cosmetics. However, this preservative is mostly found in cosmetics at about one-eighth that level [Maier et al., 2009]. IPBC Toxicity and Safety Tests show it to be generally safe: When used properly in leave-on skin products, IPBC is extremely safe [Steinberg, 2002]. Previous to being approved for cosmetic use in 1996, extensive safety and toxicity tests were conducted on IPBC and their results were gathered along with earlier studies in a report of the Safety Assessment of IPBC by the Cosmetic Ingredient Review [CIR Final Report, Lanigan 1998]. This final report found IPBC to be a non-carcinogen with no genotoxicity and in reproductive and developmental toxicity studies using rats and mice, IPBC had no significant effect on fertility, reproductive performance, or on the incidence of fetal malformation [Lanigan, 1998].

2. Specification of IPBC

Appearance: White or off white crystal or crystalline powder

Purity (HPLC): 99.0%min.

Melting point: 64-68°C

Moisture : 0.2%max.

3. Application of IPBC

a. Treatment of freshly sawn lumber

b. In-can preservative for paints

c. Mildewcide for paper industry

d. Preservative for cosmetics